Literature Highlight: OnabotulinumtoxinA for Urgency Urinary Incontinence
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چکیده
Urinary incontinence is a prevalent condition affecting a disproportionate number of older women in the United States. Anticholinergic medications are the preferred treatment; however, a single anticholinergic agent has not emerged as the best treatment option. OnabotulimumtoxinA appears effective in the treatment of urgency urinary incontinence; however, it has led to incomplete voiding and the need for self catheterization in previous trials utilizing higher doses. A double-blind, double -dummy, controlled trial compared the efficacy and safety of onabotulinumtoxinA and anticholinergic medications for urgency urinary incontinence.
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Commentary on: Anticholinergic therapy vs onabotulinumtoxinA for urgency urinary incontinence.
BACKGROUND Anticholinergic medications and onabotulinumtoxinA are used to treat urgency urinary incontinence, but data directly comparing the two types of therapy are needed. METHODS We performed a double-blind, double-placebo-controlled, randomized trial involving women with idiopathic urgency urinary incontinence who had five or more episodes of urgency urinary incontinence per 3-day period...
متن کاملComparative assessment of onabotulinumtoxinA and mirabegron for overactive bladder: an indirect treatment comparison.
CONTEXT OnabotulinumtoxinA and mirabegron have recently gained marketing authorisation to treat symptoms of overactive bladder (OAB). OBJECTIVE To evaluate the relative efficacy of mirabegron and onabotulinumtoxinA in patients with idiopathic OAB. DESIGN Network meta-analysis. DATA SOURCES A search of 9 electronic databases, review documents, guidelines and websites. METHODS Randomised ...
متن کاملAdvances in the Treatment of Urinary Incontinence in Women
ABSTR ACT: Urinary incontinence in women is quite prevalent today and management can be costly. Urinary incontinence can be minimal or quite bothersome, limiting activities of daily living. It is subdivided into urgency urinary incontinence, stress urinary incontinence, and mixed urinary incontinence. As such, treatment can vary immensely depending on the clinical presentations, ranging from be...
متن کاملWhat is the feasibility of switching to 200IU OnabotulinumtoxinA in patients with detrusor overactivity who have previously received 300IU?
INTRODUCTION To assess the feasibility of converting from 300IU to 200IU OnabotulinumtoxinA in patients diagnosed with either idiopathic detrusor overactivity (IDO) or neurogenic detrusor overactivity (NDO). MATERIAL AND METHODS Retrospective case-notes review of patients who were converted from 300IU to 200IU OnabotulinumtoxinA. Subjective patient reported improvements at interview and bladd...
متن کاملUrinary incontinence in women.
Urinary incontinence affects women of all ages. History, physical examination, and certain tests can guide specialists in diagnosing stress urinary incontinence, urgency urinary incontinence, and mixed urinary incontinence. First line management includes lifestyle and behavior modification, as well as pelvic floor strength and bladder training. Drug therapy is helpful in the treatment of urgenc...
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تاریخ انتشار 2013